TRELAGET 100MG TAB 4S
Trelaget 100mg Tablets Online At Best Price In Pakistan
Ā
Generic: Trelagliptin Succinate 100mg
Manufacturer: Getz Pharma
Quantity:
4 Tablets
INDICATION
Trelaget 100mg Tab is a once-weekly DPP-4 inhibitor prescribed as an adjunct to diet and exercise for the improvement of glycemic control in adults with type 2 diabetes mellitus. It represents a significant advancement in diabetes management, as its unique pharmacokinetics allow sustained DPP-4 inhibition for seven days with a single oral dose. This reduces the daily pill burden from 30 tablets per month to just 4, dramatically improving patient adherence. It is suitable as monotherapy when metformin is not tolerated, and as add-on therapy with other antidiabetic agents when blood sugar remains inadequately controlled, offering effective HbA1c reduction with a low risk of hypoglycemia.
MECHANISM OF ACTION
Trelagliptin inhibits the DPP-4 enzyme with exceptional potency and a prolonged binding duration of approximately 30 minutes, compared to seconds for daily DPP-4 inhibitors. This slow dissociation rate means that even one week after a single dose, DPP-4 inhibition remains around 77%. By blocking DPP-4, trelagliptin prevents the breakdown of incretin hormones GLP-1 and GIP. These incretins signal the pancreas to produce more insulin after meals and reduce glucagon from the liver, both in a glucose-dependent manner that prevents dangerous hypoglycemia. This dual hormonal effect lowers fasting and postprandial blood glucose effectively throughout the week.
DOSAGE AND ADMINISTRATION
ā¢Ā Ā Ā Ā Ā Recommended dose: 100mg orally once weekly, on the same day each week.
ā¢Ā Ā Ā Ā Ā May be taken with or without food.
ā¢Ā Ā Ā Ā Ā Swallow tablets whole with water; do not crush, break, or chew.
ā¢Ā Ā Ā Ā Ā If a dose is missed, take it as soon as remembered but never take two doses in the same week.
ā¢Ā Ā Ā Ā Ā For patients with moderate renal impairment (eGFR 30-59), reduce dose to 50mg once weekly; for severe impairment, 25mg once weekly.
SIDE EFFECTS
ā¢Ā Ā Ā Ā Ā Common: Nasopharyngitis, upper respiratory tract infection, headache, mild stomach upset.
ā¢Ā Ā Ā Ā Ā Less common: Skin rash, pruritus, elevated liver enzymes, atrial fibrillation (rare), pancreatitis (rare).
NOT RECOMMENDED IN
Trelaget 100mg Tab is not recommended for type 1 diabetes or diabetic ketoacidosis. Patients with severe renal impairment require a dose reduction. It should be used with caution in patients with a history of pancreatitis. Patients with known hypersensitivity to trelagliptin or other DPP-4 inhibitors should avoid this medication.
DRUG INTERACTIONS
Trelagliptin has a low potential for drug interactions due to its minimal hepatic metabolism and predominantly renal excretion. When combined with insulin or sulfonylureas, the risk of hypoglycemia increases, ,and dose reductions of those agents may be necessary. Drugs that impair renal function may alter trelagliptin clearance and require monitoring. No clinically significant interactions with metformin, pioglitazone, or statins have been reported.
STORAGE INSTRUCTIONS
Store at room temperature below 30Ā°C. Protect from sunlight and moisture. Keep in original sealed packaging. Store out of reach of children. Do not use after the expiry date on the carton.
WHERE TO BUY
Dawa Healthcare Pharmacy is a dependable source for patients who want to buy Trelaget 100mg Tab 4s online in Pakistan, offering Getz Pharma's innovative once-weekly diabetes tablet with fast and reliable delivery. For those comparing the Trelaget 100mg tablets 4s price in Pakistan, our website provides clear and up-to-date pricing. Order Trelaget 100mg Tab online today and enjoy same-day delivery within Karachi, while our trusted courier services deliver across every city and province of Pakistan. Reach our pharmaceutical team via WhatsApp or visit any of our multiple Karachi branches for medication management guidance.
Ā
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
Trelaget 100mg Tablets Online At Best Price In Pakistan
Ā
Generic: Trelagliptin Succinate 100mg
Manufacturer: Getz Pharma
Quantity:
4 Tablets
INDICATION
Trelaget 100mg Tab is a once-weekly DPP-4 inhibitor prescribed as an adjunct to diet and exercise for the improvement of glycemic control in adults with type 2 diabetes mellitus. It represents a significant advancement in diabetes management, as its unique pharmacokinetics allow sustained DPP-4 inhibition for seven days with a single oral dose. This reduces the daily pill burden from 30 tablets per month to just 4, dramatically improving patient adherence. It is suitable as monotherapy when metformin is not tolerated, and as add-on therapy with other antidiabetic agents when blood sugar remains inadequately controlled, offering effective HbA1c reduction with a low risk of hypoglycemia.
MECHANISM OF ACTION
Trelagliptin inhibits the DPP-4 enzyme with exceptional potency and a prolonged binding duration of approximately 30 minutes, compared to seconds for daily DPP-4 inhibitors. This slow dissociation rate means that even one week after a single dose, DPP-4 inhibition remains around 77%. By blocking DPP-4, trelagliptin prevents the breakdown of incretin hormones GLP-1 and GIP. These incretins signal the pancreas to produce more insulin after meals and reduce glucagon from the liver, both in a glucose-dependent manner that prevents dangerous hypoglycemia. This dual hormonal effect lowers fasting and postprandial blood glucose effectively throughout the week.
DOSAGE AND ADMINISTRATION
ā¢Ā Ā Ā Ā Ā Recommended dose: 100mg orally once weekly, on the same day each week.
ā¢Ā Ā Ā Ā Ā May be taken with or without food.
ā¢Ā Ā Ā Ā Ā Swallow tablets whole with water; do not crush, break, or chew.
ā¢Ā Ā Ā Ā Ā If a dose is missed, take it as soon as remembered but never take two doses in the same week.
ā¢Ā Ā Ā Ā Ā For patients with moderate renal impairment (eGFR 30-59), reduce dose to 50mg once weekly; for severe impairment, 25mg once weekly.
SIDE EFFECTS
ā¢Ā Ā Ā Ā Ā Common: Nasopharyngitis, upper respiratory tract infection, headache, mild stomach upset.
ā¢Ā Ā Ā Ā Ā Less common: Skin rash, pruritus, elevated liver enzymes, atrial fibrillation (rare), pancreatitis (rare).
NOT RECOMMENDED IN
Trelaget 100mg Tab is not recommended for type 1 diabetes or diabetic ketoacidosis. Patients with severe renal impairment require a dose reduction. It should be used with caution in patients with a history of pancreatitis. Patients with known hypersensitivity to trelagliptin or other DPP-4 inhibitors should avoid this medication.
DRUG INTERACTIONS
Trelagliptin has a low potential for drug interactions due to its minimal hepatic metabolism and predominantly renal excretion. When combined with insulin or sulfonylureas, the risk of hypoglycemia increases, ,and dose reductions of those agents may be necessary. Drugs that impair renal function may alter trelagliptin clearance and require monitoring. No clinically significant interactions with metformin, pioglitazone, or statins have been reported.
STORAGE INSTRUCTIONS
Store at room temperature below 30Ā°C. Protect from sunlight and moisture. Keep in original sealed packaging. Store out of reach of children. Do not use after the expiry date on the carton.
WHERE TO BUY
Dawa Healthcare Pharmacy is a dependable source for patients who want to buy Trelaget 100mg Tab 4s online in Pakistan, offering Getz Pharma's innovative once-weekly diabetes tablet with fast and reliable delivery. For those comparing the Trelaget 100mg tablets 4s price in Pakistan, our website provides clear and up-to-date pricing. Order Trelaget 100mg Tab online today and enjoy same-day delivery within Karachi, while our trusted courier services deliver across every city and province of Pakistan. Reach our pharmaceutical team via WhatsApp or visit any of our multiple Karachi branches for medication management guidance.
Ā
