Sitaglu Met Xr 50/500mg Tablets Online At Best Price In Pakistan

 

Generic: Sitagliptin 50mg + Metformin HCl 500mg (Extended Release)

Manufacturer: Hilton Pharma

Quantity:

28 tablets per pack

INDICATION

Sitaglu Met XR 50/500mg Tab is a lower-dose extended-release combination tablet prescribed for adults with type 2 diabetes mellitus who are initiating combination therapy, transitioning from immediate-release metformin formulations, or require a gentler dose titration plan. The extended-release technology provides a more gradual and sustained release of metformin, significantly reducing gastrointestinal intolerance while maintaining effective glucose control.

MECHANISM OF ACTION

Sitagliptin acts as a selective DPP-4 inhibitor, preventing the enzyme from inactivating GLP-1 and GIP incretin hormones. These preserved incretins enhance glucose-dependent insulin secretion from the pancreas and suppress glucagon release, targeting blood sugar elevations without causing hypoglycemia as a standalone effect. Metformin XR reduces hepatic glucose output by inhibiting gluconeogenesis and glycogenolysis in the liver, improves peripheral insulin sensitivity in muscles, and modestly decreases intestinal glucose absorption.

DOSAGE AND ADMINISTRATION

•      Usual starting dose: One tablet (50mg/500mg XR) once or twice daily with meals, as directed by the physician.

•      Swallow tablets whole; do not break, crush, or chew the extended-release formulation.

•      Take consistently with meals, preferably the evening meal, to minimize gastrointestinal effects.

•      Dosing frequency and duration are determined by the physician based on HbA1c and renal function.

SIDE EFFECTS

•      Common: Mild nausea, diarrhea, abdominal discomfort, headache, metallic taste (less frequent with XR than immediate-release).

•      Less common: Pancreatitis (rare), upper respiratory infection, hypoglycemia when used with insulin or sulfonylureas, lactic acidosis (very rare).

NOT RECOMMENDED IN

Sitaglu Met XR 50/500mg Tab is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min), metabolic acidosis, or type 1 diabetes. It should be withheld before contrast-based imaging and resumed only after renal function is confirmed normal. Not suitable in cases of significant hepatic impairment or known hypersensitivity to sitagliptin or metformin. Patients requiring surgery or facing acute serious illness should pause this medication and consult their physician.

DRUG INTERACTIONS

Iodinated contrast media used in imaging can cause temporary renal dysfunction and risk of metformin accumulation, potentially causing lactic acidosis; pause therapy accordingly. Combining sitagliptin with insulin or sulfonylureas raises hypoglycemia risk, requiring dose adjustments. Cimetidine and other drugs excreted via renal tubular secretion may increase metformin concentrations. Carbonic anhydrase inhibitors may increase the risk of metabolic acidosis. Patients must provide a complete medication list to their physician before starting this therapy.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 30°C. Protect from moisture and light. Keep in original sealed packaging. Store out of reach of children. Do not use after the expiry date on the carton.

WHERE TO BUY

Dawa Healthcare Pharmacy is the go-to platform for patients who need to buy Sitaglu Met XR 50/500mg Tab online in Pakistan with the convenience of home delivery and the certainty of authentic, quality-assured medications. Patients checking the Sitaglu Met XR 50/500mg tablets price in Pakistan will find our pricing is consistent and clearly displayed on the website. Order Sitaglu Met XR 50/500mg Tab online and enjoy same-day delivery in Karachi for orders placed before the daily cut-off, along with nationwide courier delivery across Pakistan. Our WhatsApp line and multiple Karachi branches are always available for diabetes care support.