Sitaglu Met 50+500mg Tablets Online At Best Price In Pakistan

 

Generic: Sitagliptin 50mg + Metformin HCl 500mg

Manufacturer: Hilton Pharma

Quantity: 28 Tablets

INDICATION

Sitaglu Met 50mg+500mg Tab is a fixed-dose combination antidiabetic medication prescribed as an adjunct to diet and exercise for the management of type 2 diabetes mellitus in adults. It is indicated when blood sugar is inadequately controlled on metformin or sitagliptin alone, or as a suitable initial combination therapy. By combining two complementary mechanisms in a single tablet, it improves fasting and postprandial blood glucose levels, lowers HbA1c, and reduces the risk of diabetic complications, including neuropathy, retinopathy, and nephropathy. It simplifies the treatment regimen, improving patient adherence over the course of long-term diabetes management.

MECHANISM OF ACTION

This combination works through two different but complementary pathways. Sitagliptin is a DPP-4 inhibitor that prevents the breakdown of incretin hormones, particularly GLP-1 and GIP. These hormones tell the pancreas to release more insulin when blood sugar is high and tell the liver to stop releasing stored glucose, both in a glucose-dependent manner that avoids dangerous low blood sugar. Metformin reduces the amount of glucose the liver produces and releases into the blood, improves the body's sensitivity to its own insulin, and lowers glucose absorption from the gut. Together, they control blood sugar from multiple angles effectively.

DOSAGE AND ADMINISTRATION

•      Usual dose: One tablet (50mg/500mg) twice daily, taken with meals to reduce gastrointestinal side effects.

•      Swallow whole with a full glass of water; do not crush, split, or chew the tablet.

•      Dose may be adjusted based on HbA1c targets and renal function by the physician.

•      Take at the same time each day to maintain consistent blood sugar control.

•      Never skip doses; if a dose is missed, take it with the next meal and do not double up.

 

SIDE EFFECTS

•      Common: Nausea, diarrhea, abdominal discomfort, metallic taste in the mouth, headache.

•      Less common: Pancreatitis (rare), upper respiratory tract infection, nasopharyngitis, hypoglycemia when combined with insulin or sulfonylureas.

NOT RECOMMENDED IN

Sitaglu Met 50mg+500mg Tab is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min), metabolic acidosis, including diabetic ketoacidosis, or type 1 diabetes. It must be discontinued before iodinated contrast procedures and in situations of acute illness, dehydration, or surgery. It is not suitable for patients with significant hepatic impairment or hypersensitivity to either sitagliptin or metformin. Safety during pregnancy is not clearly established; consult a physician.

DRUG INTERACTIONS

Contrast media used in imaging procedures can cause acute renal impairment and metformin accumulation, potentially leading to lactic acidosis; metformin must be stopped before such procedures. Alcohol increases the risk of lactic acidosis with metformin and should be avoided. Carbonic anhydrase inhibitors, such as topiramate, can promote metabolic acidosis. Sitagliptin may interact with insulin and sulfonylureas, increasing hypoglycemia risk. Cationic drugs that compete for renal tubular secretion may reduce metformin clearance. All medications should be disclosed to the physician before initiating combination therapy.

STORAGE INSTRUCTIONS

Store at room temperature between 20°C and 25°C. Keep away from light, moisture, and heat. Store in original packaging. Keep out of reach of children and pets. Do not use after the expiry date on the carton.

WHERE TO BUY

Dawa Healthcare Pharmacy allows you to easily buy Sitaglu Met 50mg+500mg Tab 28s online in Pakistan, giving diabetes patients across the country access to authentic medication. Patients checking the Sitaglu Met 50mg+500mg tablets 28s price in Pakistan can view competitive and clearly displayed pricing on our platform. Order Sitaglu Met 50mg+500mg Tab online today and get same-day delivery across Karachi, while we provide reliable courier delivery to all cities nationwide. You can also connect with our team via WhatsApp or visit any of our Karachi branches for expert guidance and support regarding your diabetes medication.