Semma 3mg Tablets Online At Best Price In Pakistan

Generic: Semaglutide 3mg

Manufacturer: Horizon Pharmaceuticals

Quantity:

30 tablets per pack

INDICATION

Semma 3mg Tablet is the initial titration dose of oral semaglutide, a GLP-1 receptor agonist used as an adjunct to diet and exercise in adults with type 2 diabetes mellitus. The 3mg dose is not intended for glycemic control but is prescribed to help the body gradually adjust to semaglutide therapy, reducing the incidence of gastrointestinal side effects such as nausea and vomiting before progressing to the therapeutic doses of 7mg and 14mg. Starting at this low dose ensures better patient tolerability and sustained adherence to semaglutide treatment over the long term.

MECHANISM OF ACTION

Semaglutide mimics a natural hormone called GLP-1 (glucagon-like peptide-1) that the gut releases after a meal. This hormone tells the pancreas to produce more insulin when blood sugar is high, reduces glucagon (a hormone that raises blood sugar), and slows how fast food leaves the stomach, making you feel fuller for longer. Semaglutide does all these things in a more potent and sustained way than the body's own GLP-1 because it resists enzymatic breakdown. The result is better blood sugar control, reduced appetite, and gradual weight loss.

DOSAGE AND ADMINISTRATION

•      Take one 3mg tablet once daily in the morning, on an empty stomach.

•      Swallow whole with approximately 120ml of plain water; do not use other beverages.

•      Wait at least 30 minutes before eating, drinking, or taking other oral medicines.

•      The 3mg dose is intended for the first month only to allow tolerance; do not remain on 3mg long-term.

•      After four weeks, the physician will typically increase the dose to 7mg.

 

SIDE EFFECTS

•      Common: Nausea, vomiting, diarrhea, decreased appetite, abdominal discomfort.

•      Less common: Constipation, bloating, heartburn, fatigue, hypoglycemia when combined with insulin or sulfonylureas.

NOT RECOMMENDED IN

Semma is not recommended in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2 (MEN-2). It is not indicated for type 1 diabetes or diabetic ketoacidosis. Use with caution in patients with a history of pancreatitis; the drug should be discontinued if pancreatitis is confirmed. It is not recommended for patients with severe gastrointestinal disease.

DRUG INTERACTIONS

Semaglutide slows gastric emptying, which can affect the absorption rate and peak concentration of other orally administered medications. Co-administration with insulin or sulfonylureas significantly increases the risk of hypoglycemia; dose reductions of those agents may be required. DPP-IV inhibitors should generally not be combined with GLP-1 agonists due to overlapping mechanisms.

STORAGE INSTRUCTIONS

Store at room temperature below 30°C. Protect from moisture and light. Keep in original sealed packaging. Store out of reach of children. Do not use after the expiry date printed on the pack.

WHERE TO BUY

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