RATNOX 100MG CAPSULE ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Itraconazole 100mg

MANUFACTURER: True Care Pharma (Pvt) Ltd

QUANTITY:

4 capsules per pack

INDICATION

Ratnox 100mg Cap is a broad-spectrum triazole antifungal indicated for the treatment of systemic and superficial fungal infections including aspergillosis, candidiasis, cryptococcosis, histoplasmosis, blastomycosis, onychomycosis (nail fungus), tinea versicolor, and other dermatophyte infections in immunocompromised and non-immunocompromised patients.

MECHANISM OF ACTION

Itraconazole inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, which is required for the conversion of lanosterol to ergosterol, the primary sterol component of the fungal cell membrane. Depletion of ergosterol causes accumulation of toxic sterols, impairs membrane integrity and permeability, and ultimately leads to fungal cell death. Itraconazole has a broader spectrum than fluconazole, including activity against Aspergillus species, and its highly lipophilic nature ensures excellent tissue penetration into skin, nails, and lungs.

DOSAGE AND ADMINISTRATION

•      Onychomycosis (pulse therapy): 200mg twice daily for 1 week per month for 2 to 3 months

•      Systemic fungal infections: 200mg once or twice daily for 3 months depending on infection

•      Take capsules with a full meal to maximize absorption (food increases bioavailability by 30%)

•      Always follow the dosage and duration prescribed by your doctor

SIDE EFFECTS

Common:

•      Nausea, abdominal pain, dyspepsia

•      Headache and dizziness

•      Elevated liver enzymes

•      Skin rash

Less common:

•      Hepatotoxicity and liver failure (monitor LFTs in prolonged therapy)

•      Heart failure with negative inotropic effect at higher doses

•      Peripheral neuropathy with prolonged use

•      Hypokalaemia

NOT RECOMMENDED IN

•      Known hypersensitivity to itraconazole or other triazole antifungals

•      Heart failure (negative inotropic effect)

•      Concurrent use with drugs contraindicated with strong CYP3A4 inhibitors

•      Pregnancy (teratogenic in animals; use only if benefit outweighs risk with reliable contraception)

DRUG INTERACTIONS

Itraconazole is a potent CYP3A4 inhibitor and significantly increases plasma levels of many drugs, including statins (rhabdomyolysis risk; avoid simvastatin and lovastatin), cyclosporine, tacrolimus, digoxin, midazolam, triazolam, and many cardiovascular drugs. It is contraindicated with cisapride, astemizole, terfenadine, pimozide, quinidine, and ergot alkaloids. Rifampicin, isoniazid, and carbamazepine reduce itraconazole levels. H2-blockers and PPIs reduce itraconazole absorption by reducing gastric acidity.

STORAGE INSTRUCTIONS

Store below 25°C in a dry place away from direct sunlight. Keep in original packaging. Keep out of reach of children.

WHERE TO BUY

You can buy Ratnox 100mg capsule online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Ratnox 100mg cap price in Pakistan and learn about Ratnox 100mg capsule uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Ratnox 100mg capsule uses, pricing, and order placement.