PROLIA 60MG INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Denosumab 60mg/1ml

MANUFACTURER: AMGEN

QUANTITY:

Single pre-filled syringe, 1ml

INDICATION

Prolia 60mg Inj is a RANK ligand (RANKL) inhibitor indicated for the treatment of postmenopausal osteoporosis in women at increased risk of fractures, treatment of bone loss in men with prostate cancer on androgen deprivation therapy, and treatment of bone loss in women with breast cancer on aromatase inhibitor therapy.

MECHANISM OF ACTION

Denosumab is a fully human monoclonal antibody (IgG2) that binds with high affinity and specificity to RANK ligand (RANKL), a cytokine that is essential for the formation, function, and survival of osteoclasts. By blocking RANKL from binding to its receptor RANK on osteoclast precursors and mature osteoclasts, denosumab inhibits osteoclast differentiation, reduces osteoclast activity and lifespan, and thereby decreases bone resorption. This shifts the bone remodeling balance toward bone formation, increasing bone mineral density and reducing fracture risk.

DOSAGE AND ADMINISTRATION

•      Adults: 60mg subcutaneous injection once every 6 months

•      Administer in the upper arm, upper thigh, or abdomen

•      Supplement with calcium 1000mg and vitamin D at least 400 IU daily during treatment

•      Administered by a trained healthcare professional; do not self-inject without medical training

SIDE EFFECTS

Common:

•      Back pain, extremity pain, musculoskeletal pain

•      Hypocalcemia (low calcium), particularly in patients with vitamin D deficiency

•      Nasopharyngitis and upper respiratory tract infection

•      Urinary tract infection

Less common:

•      Osteonecrosis of the jaw (rare; risk higher in patients on high-dose cancer therapy)

•      Atypical femoral fractures with very long-term use

•      Serious infections including cellulitis and endocarditis (immune modulation)

•      Hypersensitivity reactions including anaphylaxis

NOT RECOMMENDED IN

•      Hypocalcemia (must be corrected before initiating therapy)

•      Known hypersensitivity to denosumab

•      Pregnancy (may cause fetal harm)

•      Dental procedures requiring tooth extraction or oral surgery should be completed before initiating therapy

DRUG INTERACTIONS

Concomitant use of other bone-modifying agents such as bisphosphonates may theoretically produce additive effects; not routinely combined. Systemic corticosteroids increase fracture risk and may compound bone loss; ensure adequate supplementation is maintained. Denosumab is a monoclonal antibody and is not metabolized by CYP450 enzymes; pharmacokinetic drug interactions are unlikely. Calcium and vitamin D supplementation is mandatory during therapy.

STORAGE INSTRUCTIONS

Store between 2°C and 8°C (refrigerate). Protect from light. Do not shake. Allow to reach room temperature before administration. Keep out of reach of children.

WHERE TO BUY

You can buy Prolia 60mg Inj online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Prolia 60mg Inj price in Pakistan and learn about Prolia 60mg Inj uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Prolia 60mg Inj uses, pricing, and order placement.