PRESTIA 1G INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Methylprednisolone Sodium Succinate 1g

MANUFACTURER: Horizon Pharmaceuticals (Pvt) Ltd

QUANTITY:

Single vial for injection

INDICATION

Prestia 1G Inj is a high-dose intravenous corticosteroid indicated for pulse therapy in severe and life-threatening inflammatory and autoimmune conditions. It is used in acute exacerbations of multiple sclerosis, lupus nephritis, severe organ transplant rejection, severe autoimmune conditions such as pemphigus and dermatomyositis, and other conditions requiring rapid, potent, short-course immunosuppression.

MECHANISM OF ACTION

At the 1g pulse dose, methylprednisolone achieves supraphysiological plasma concentrations that produce profound immunosuppression beyond standard anti-inflammatory glucocorticoid effects. In addition to genomic effects via glucocorticoid receptors, high-dose methylprednisolone exerts rapid non-genomic effects by directly interacting with cell membranes, inhibiting immune cell activation, reducing lymphocyte and neutrophil function, and suppressing complement activation. This rapid immunosuppression is particularly effective in arresting acute inflammatory cascades in autoimmune and allograft rejection episodes.

DOSAGE AND ADMINISTRATION

•      Pulse therapy: 1g by slow intravenous infusion over 30 to 60 minutes once daily for 3 to 5 consecutive days

•      Multiple sclerosis relapse: 1g IV once daily for 3 to 5 days

•      Transplant rejection: as prescribed by the transplant specialist

•      Administered only by a trained healthcare professional in a hospital or clinical setting with cardiac monitoring

SIDE EFFECTS

Common:

•      Flushing, metallic taste, and palpitations during infusion

•      Hyperglycemia (monitor blood glucose closely during pulse therapy)

•      Elevated blood pressure and fluid retention

•      Insomnia, euphoria, or mood disturbances

Less common:

•      Cardiac arrhythmias, including bradycardia and ventricular fibrillation (rare; administer slowly and monitor ECG)

•      Anaphylaxis (rare)

•      Severe infections due to profound immunosuppression

•      Avascular necrosis of bone with repeated pulse courses

NOT RECOMMENDED IN

•      Systemic fungal infections

•      Known hypersensitivity to methylprednisolone or any excipient

•      Rapid intravenous bolus administration (must be infused slowly over 30 to 60 minutes to prevent cardiac arrhythmia)

•      Active peptic ulcer, uncontrolled diabetes, or severe hypertension without close monitoring

DRUG INTERACTIONS

NSAIDs significantly increase gastrointestinal ulceration risk with high-dose corticosteroids; use with extreme caution. CYP3A4 inhibitors including ketoconazole, ritonavir, and clarithromycin increase methylprednisolone plasma levels and systemic effects. Cyclosporine and methylprednisolone mutually inhibit each other's metabolism via CYP3A4, increasing levels of both; monitor closely in transplant settings. Live vaccines are contraindicated during high-dose corticosteroid therapy due to risk of disseminated infection.

STORAGE INSTRUCTIONS

Store unconstituted vials below 25°C away from direct light. Use reconstituted solution immediately. Do not freeze. Keep out of reach of children.

WHERE TO BUY

You can buy Prestia 1g Inj IM/IV online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Prestia 1g Inj IM/IV price in pakistan and learn about Prestia 1g Inj IM/IV uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Prestia 1g Inj IM/IV uses, pricing, and order placement.