PRESTIA 125MG INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Methylprednisolone Sodium Succinate 125mg

MANUFACTURER: Horizon Pharmaceuticals (Pvt) Ltd

QUANTITY:

Single vial for injection

INDICATION

Prestia 125mg Inj is a corticosteroid indicated for the management of severe inflammatory, allergic, and immunological conditions requiring rapid and potent anti-inflammatory therapy. It is used in acute exacerbations of asthma, severe allergic reactions, autoimmune conditions, spinal cord injury, and as part of immunosuppressive regimens in organ transplantation.

MECHANISM OF ACTION

Methylprednisolone is a synthetic glucocorticoid that binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates the transcription of anti-inflammatory and immunosuppressive genes. It inhibits the synthesis of pro-inflammatory cytokines, reduces vascular permeability, suppresses leukocyte migration to sites of inflammation, and stabilises lysosomal membranes. The sodium succinate ester is water-soluble, allowing intravenous or intramuscular administration for rapid systemic effect in acute settings.

DOSAGE AND ADMINISTRATION

•      Adults: 10 to 500mg by IV or IM injection depending on condition and severity

•      Acute severe asthma or allergic reaction: 40 to 125mg IV or IM as a single or repeat dose

•      Spinal cord injury: high-dose protocol as directed by a specialist

•      Administered by a trained healthcare professional; dosage and route determined by the prescribing physician

SIDE EFFECTS

Common:

•      Elevated blood glucose (hyperglycemia), particularly in diabetic patients

•      Fluid retention and oedema

•      Elevated blood pressure

•      Insomnia and mood changes with repeated doses

Less common:

•      Adrenal suppression with prolonged or repeated high-dose use

•      Increased susceptibility to infections

•      Peptic ulceration with concurrent NSAID use

•      Osteoporosis and avascular necrosis with prolonged systemic corticosteroid therapy

NOT RECOMMENDED IN

•      Systemic fungal infections (unless used as part of specific management)

•      Known hypersensitivity to methylprednisolone or any excipient

•      Live vaccines should not be administered during systemic corticosteroid therapy

•      Use with caution in patients with diabetes, hypertension, peptic ulcer, or active infections

DRUG INTERACTIONS

NSAIDs combined with methylprednisolone significantly increase the risk of gastrointestinal ulceration and bleeding; avoid concurrent use where possible. CYP3A4 inhibitors such as ketoconazole, clarithromycin, and ritonavir increase methylprednisolone plasma levels, enhancing both efficacy and side effects; dose reduction may be required. CYP3A4 inducers such as rifampicin, carbamazepine, and phenytoin reduce methylprednisolone efficacy. Concurrent use with cyclosporine increases levels of both drugs through mutual CYP3A4 inhibition.

STORAGE INSTRUCTIONS

Store unconstituted vials below 25°C away from direct light. Use reconstituted solution immediately or within the stability period stated on the label. Keep out of reach of children.

WHERE TO BUY

You can buy Prestia 125mg Inj IM/IV online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Prestia 125mg Inj IM/IV price in pakistan and learn about Prestia 125mg Inj IM/IV uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Prestia 125mg Inj IM/IV uses, pricing, and order placement.