PETRA 40MG INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Esomeprazole

MANUFACTURER: Neutro Pharma (Pvt) Ltd

QUANTITY:

Single vial for injection

INDICATION

Petra 40mg Inj is an intravenous proton pump inhibitor indicated for the short-term treatment of gastro-esophageal reflux disease and erosive esophagitis when the oral route is not possible. It is also used in the management of upper gastrointestinal bleeding from peptic ulcers, pathological hypersecretory conditions including Zollinger-Ellison syndrome, and in post-surgical patients requiring acid suppression.

MECHANISM OF ACTION

Esomeprazole is the S-enantiomer of omeprazole and a selective, irreversible proton pump inhibitor. After intravenous administration, it is activated in the acidic environment of the gastric parietal cell canaliculi, where it forms a covalent sulphenamide bond with cysteine residues on the H+/K+-ATPase enzyme, blocking the final step of gastric acid secretion. Intravenous delivery bypasses gastrointestinal absorption and achieves rapid therapeutic plasma levels, making it the preferred route when patients are nil-by-mouth, critically ill, or post-operative. As the pure S-isomer, esomeprazole has a more consistent pharmacokinetic profile than racemic omeprazole across CYP2C19 metabolizer phenotypes.

DOSAGE AND ADMINISTRATION

•      Adults: 40mg once daily by slow intravenous infusion over 10 to 30 minutes

•      Upper GI bleeding: 80mg IV bolus followed by 8mg/hour continuous infusion for 72 hours

•      Zollinger-Ellison syndrome: 40mg to 80mg twice daily; titrated as needed

•      Administer by intravenous route only; switch to oral esomeprazole as soon as clinically appropriate

SIDE EFFECTS

Common:

•      Headache

•      Nausea, diarrhoea, flatulence

•      Injection site reactions with intravenous administration

•      Abdominal pain

Less common:

•      Hypomagnesaemia with prolonged intravenous therapy

•      Clostridium difficile infection risk with prolonged PPI use

•      Elevated liver enzymes

•      Anaphylaxis (rare)

NOT RECOMMENDED IN

•      Known hypersensitivity to esomeprazole, omeprazole, or other substituted benzimidazole PPIs

•      Concurrent use with atazanavir or nelfinavir (significantly reduced antiretroviral absorption)

•      Not for intramuscular injection; intravenous use only

•      Severe hepatic impairment without dose adjustment

DRUG INTERACTIONS

Esomeprazole inhibits CYP2C19 and has less effect on clopidogrel bioactivation than omeprazole, making it a preferred PPI in patients on antiplatelet therapy. It reduces absorption of atazanavir, nelfinavir, ketoconazole, and itraconazole by raising intragastric pH. Methotrexate renal excretion may be reduced by PPIs; monitor for methotrexate toxicity. Digoxin absorption may be slightly increased with concomitant PPI use.

STORAGE INSTRUCTIONS

Store unconstituted vials below 25°C away from direct light. Use reconstituted solution within the stability period stated on the label. Do not freeze. Keep out of reach of children.

WHERE TO BUY

You can buy Petra 40mg Inj online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Petra 40mg Inj price in pakistan and learn about Petra 40mg Inj uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Petra 40mg Inj uses, pricing, and order placement.