Noctamid 1mg Tablets Online At Best Price In Pakistan

GENERIC: Lormetazepam 1mg

MANUFACTURER: Bayer Pakistan

QUANTITY

100 Tablets

INDICATION

Noctamid 1mg is a benzodiazepine hypnotic indicated for the short-term management of insomnia in adults, particularly sleep-onset insomnia and sleep-maintenance insomnia characterized by frequent nocturnal awakening. It helps patients fall asleep faster, increases total sleep duration, and reduces the number of nighttime awakenings. Lormetazepam has a moderate duration of action that minimizes residual sedation the following morning, making it a preferred option compared to longer-acting benzodiazepine hypnotics.

MECHANISM OF ACTION

Lormetazepam works by enhancing the activity of GABA, a key calming neurotransmitter in the brain. It binds to specific sites on GABA-A receptors, which increases the opening of chloride channels and makes neurons less excitable. This action helps promote relaxation, reduces the time it takes to fall asleep, extends sleep duration, and minimizes nighttime awakenings. With a half-life of about 10–12 hours, lormetazepam supports restful sleep while generally avoiding significant next-day drowsiness.

DOSAGE AND ADMINISTRATION

•      Adults: 0.5–1mg taken 15–30 minutes before bedtime.

•      Elderly patients: 0.5mg is the recommended starting dose due to increased sensitivity.

•      Use for the shortest necessary duration, typically 2–4 weeks.

SIDE EFFECTS

•      Sedation and drowsiness

•      Memory impairment and anterograde amnesia

•      Dizziness and coordination difficulties

•      Dependence and tolerance with prolonged use

•      Rebound insomnia upon discontinuation

 

 

NOT RECOMMENDED IN

Noctamid 1mg is contraindicated in patients with known hypersensitivity to lormetazepam or other benzodiazepines. It must not be used in patients with sleep apnea syndrome, severe respiratory insufficiency, myasthenia gravis, or severe hepatic impairment. Not recommended during pregnancy, especially the first trimester, or during breastfeeding. Patients with a history of substance abuse, alcoholism, or benzodiazepine dependence should not receive lormetazepam. Long-term use is strongly discouraged as tolerance and physical dependence develop rapidly.

DRUG INTERACTIONS

Noctamid (Lormetazepam) can interact with alcohol and other CNS depressants, including opioids, antihistamines, and sedative antidepressants, increasing the risk of excessive sedation and respiratory depression. CYP3A4 inhibitors like ketoconazole may raise its blood levels, while inducers like rifampicin can reduce its effect. Probenecid may prolong its action. Extra caution is needed when combined with opioids due to serious CNS and respiratory risks.

STORAGE INSTRUCTIONS

Store below 25°C in a dry, cool place away from light and moisture. Keep in original packaging and out of reach of children. This is a controlled substance; store securely in a locked cabinet.

WHERE TO BUY

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