Ivabrex 5mg Tablets Online At Best Price In Pakistan

GENERIC: Ivabradine 5mg

MANUFACTURER: Horizon Pharmaceuticals

QUANTITY

30 tablets per pack

INDICATION

Ivabrex 5mg Tablet is indicated for the management of chronic stable heart failure in adult patients with reduced left ventricular ejection fraction who are in sinus rhythm with a resting heart rate of 70 bpm or higher. It is also prescribed for the treatment of stable angina pectoris to reduce the frequency and severity of angina attacks. By controlling heart rate without affecting cardiac contractility, Ivabrex improves exercise tolerance, reduces fatigue and shortness of breath, and enhances overall cardiovascular stability.

MECHANISM OF ACTION

Ivabradine selectively inhibits the pacemaker If current in the sinoatrial node of the heart by blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. This slows the spontaneous diastolic depolarization of the SA node, reducing heart rate while maintaining cardiac contractility and blood pressure. The heart rate reduction is more pronounced at higher baseline rates, allowing targeted therapy for heart failure or angina patients without compromising hemodynamics.

DOSAGE AND ADMINISTRATION

●     Adults: Start with 5mg orally twice daily with meals

●     After two weeks, the dose may increase to 7.5mg twice daily based on resting heart rate

●     In patients at risk of bradycardia, start at 2.5mg twice daily

●     Administer approximately one hour before meals

●     Maximum dose: 7.5mg twice daily

●     Follow physician guidance for angina or heart failure management

 

SIDE EFFECTS

●     Visual disturbances (phosphenes, flashes of light)

●     Bradycardia (slow heart rate)

●     Dizziness and headache

●     Blurred vision

●     Less commonly: atrial fibrillation, hypotension, first-degree heart block

NOT RECOMMENDED IN

●     Severe bradycardia (resting heart rate <60 bpm)

●     Sick sinus syndrome or sinoatrial block

●     Severe liver disease

●     Hypotension

●     Dependency on a pacemaker

●     Pregnancy and breastfeeding

●     Children and adolescents under 18 years

DRUG INTERACTIONS

Ivabradine may interact with medications affecting heart rate or cardiac conduction. Combining it with calcium channel blockers such as verapamil or diltiazem significantly increases bradycardia risk and should be avoided. Ketoconazole, clarithromycin, and ritonavir can elevate Ivabradine plasma levels, increasing the risk. Rifampicin may reduce efficacy. Concomitant use with other QT-prolonging drugs or beta-blockers requires caution.

STORAGE INSTRUCTIONS

Store below 30°C in a cool, dry place, away from direct sunlight, moisture, and heat. Keep in original packaging and out of reach of children. Do not use beyond the expiry date.

WHERE TO BUY

You can buy Ivabrex 5mg Tab online in Pakistan through Dawa Healthcare Pharmacy, a trusted and verified source for authentic medications. Check the latest Ivabrex 5mg tablets price in Pakistan on the website to make an informed purchase. Ordering is simple, safe, and convenient, with secure payment options and a user-friendly platform. Nationwide delivery is available, with same-day delivery in Karachi for urgent needs. Dawa Healthcare also provides prompt support and guidance via WhatsApp across all branches for any product-related queries.