INOGRAF 1MG CAPSULE ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Tacrolimus 1mg

MANUFACTURER: Platinum Pharmaceuticals

QUANTITY:

30 capsules per pack

INDICATION

Inograf 1mg Cap is an immunosuppressant indicated for the prophylaxis of organ rejection in patients who have received kidney, liver, or heart transplants. It is used as part of combination immunosuppressive regimens to prevent the body's immune system from attacking the transplanted organ.

MECHANISM OF ACTION

Tacrolimus is a calcineurin inhibitor that binds to an intracellular immunophilin protein called FK-binding protein 12 (FKBP-12). This drug-protein complex inhibits calcineurin, a phosphatase required for the activation of the nuclear factor of activated T-cells (NFAT). Blocking NFAT prevents the transcription of interleukin-2 and other cytokines essential for T-lymphocyte activation and proliferation, thereby suppressing the immune response against the transplanted organ.

DOSAGE AND ADMINISTRATION

•      Dosage is highly individualized based on transplant type, body weight, and through blood levels

•      Initial adult kidney transplant dose: typically, 0.2 to 0.3mg/kg/day in two divided doses

•      Regular therapeutic drug monitoring (trough levels) is mandatory

•      Always prescribed and monitored by a transplant specialist; never self-adjust the dose

SIDE EFFECTS

Common:

•      Tremor

•      Headache and insomnia

•      Hyperglycemia and new-onset diabetes

•      Hypertension

Less common:

•      Nephrotoxicity (dose-dependent; monitor renal function)

•      Neurotoxicity: seizures, leukoencephalopathy

•      QT prolongation and cardiac arrhythmias

•      Increased susceptibility to infections and malignancies with prolonged use

NOT RECOMMENDED IN

•      Concurrent use with cyclosporine (additive nephrotoxicity)

•      Known hypersensitivity to tacrolimus or polyoxyl 60 hydrogenated castor oil

•      Pregnancy and breastfeeding (unless benefit outweighs risk under specialist guidance)

•      Grapefruit and grapefruit juice must be avoided

DRUG INTERACTIONS

Strong CYP3A4 inhibitors including azole antifungals, macrolide antibiotics, and protease inhibitors markedly increase tacrolimus blood levels, raising toxicity risk; dose reduction and frequent monitoring required. CYP3A4 inducers such as rifampicin and St John's Wort reduce tacrolimus levels, risking rejection. NSAIDs combined with tacrolimus increase nephrotoxicity. Potassium-sparing diuretics increase hyperkalemia risk.

STORAGE INSTRUCTIONS

Store below 25°C in a dry place away from direct light. Keep in original packaging. Keep out of reach of children.

WHERE TO BUY

You can buy Inograf 1mg capsules online from Dawa Healthcare Pharmacy at dawahealthcare.biz, Pakistan's trusted source for authentic medicines with pharmacist-verified products. Check the Inograf 1mg cap price in Pakistan and learn about Inograf 1mg capsule uses directly on our product page. Our knowledgeable pharmacy team is available to answer all your questions about dosage, uses, and suitability. Same-day delivery is available for customers in Karachi, ensuring you receive your order without delay. For customers across Pakistan, Dawa Healthcare offers reliable nationwide courier service so your medicine reaches you safely and on time. You can also visit any of our Karachi branches in person or contact our responsive WhatsApp support team for quick help with Inograf 1mg capsule uses, pricing, and order placement.