GNEB 2.5 MG ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Nebivolol 2.5mg

MANUFACTURER: Genix Pharma

QUANTITY

28 tablets

INDICATION

Gneb 2.5mg is indicated for the treatment of essential hypertension in adults and as adjunctive therapy in chronic stable heart failure in patients aged 70 years and above. It reduces blood pressure and cardiovascular risk through a unique vasodilating beta-blocker mechanism.

MECHANISM OF ACTION

Nebivolol is a third-generation, highly selective beta-1 adrenergic receptor antagonist with vasodilating properties mediated by nitric oxide (NO) release from the endothelium. Beta-1 blockade reduces heart rate, cardiac output, and myocardial oxygen demand. The NO-mediated vasodilation reduces peripheral vascular resistance, further lowering blood pressure. This dual mechanism distinguishes nebivolol from older beta-blockers and results in favorable hemodynamic and metabolic effects including preservation of glucose tolerance and lipid profiles.

DOSAGE AND ADMINISTRATION

●     Adults: 2.5mg once daily, which may be increased to 5mg daily after 2 weeks based on response

●     For heart failure: start at 1.25mg daily and titrate slowly under medical supervision

●     Take at the same time each day, with or without food

●     Swallow whole with water

●     Do not discontinue abruptly; taper over 1 to 2 weeks

●     Dose adjustment required in hepatic or renal impairment

SIDE EFFECTS

Common:

●     Headache

●     Fatigue or dizziness

●     Bradycardia

Less common:

●     Peripheral edema

●     Nausea or diarrhea

●     Cold extremities

●     Worsening of heart failure symptoms at initiation

NOT RECOMMENDED IN

●     Severe bradycardia or heart rate below 60 bpm

●     Uncontrolled heart failure

●     Cardiogenic shock

●     Severe hepatic impairment

●     Asthma or severe COPD

●     Known hypersensitivity to nebivolol

DRUG INTERACTIONS

Calcium channel blockers such as verapamil may cause severe bradycardia or heart block. Clonidine withdrawal may be exaggerated when combined with beta-blockers. CYP2D6 inhibitors such as fluoxetine and paroxetine may increase nebivolol plasma levels. Concurrent antihypertensives may have additive blood pressure lowering effects. Insulin-treated diabetics should be aware that nebivolol may mask hypoglycemia symptoms.

STORAGE INSTRUCTIONS

Store below 25 degrees Celsius. Protect from moisture and light. Keep in original packaging. Keep out of reach of children.

WHERE TO BUY

You can buy Gneb 2.5mg 28S online from Dawa Healthcare Pharmacy, your trusted source for authentic cardiovascular medications in Pakistan. Check the Gneb 2.5mg price in Pakistan and learn about its uses through our pharmacist-verified team. Same-day delivery is available across Karachi. Nationwide courier service delivers anywhere in Pakistan. Contact us via WhatsApp or visit any of our Karachi branches for prompt and reliable service.