AMROVIL INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Pheniramine Maleate 22.75mg/ml (25mg/ml)

MANUFACTURER: Amros Pharmaceuticals (Pvt) Ltd

QUANTITY:

Vial/Ampoule

INDICATION

Amrovil Injection is a first-generation antihistamine used in the management of allergic conditions including hay fever, allergic rhinitis, urticaria (hives), angioedema, conjunctivitis, and skin reactions such as redness and itching. It is also used as an adjunct in the treatment of anaphylaxis and severe allergic reactions when given alongside epinephrine. The injectable form is particularly useful in acute allergic emergencies requiring rapid onset of action.

MECHANISM OF ACTION

Pheniramine maleate acts as a competitive antagonist at peripheral H1 histamine receptors. It competes with histamine for binding at effector cell receptor sites on blood vessels, bronchial smooth muscle, and secretory glands. By occupying these receptors, it prevents histamine from triggering vasodilation, increased vascular permeability, bronchoconstriction, and mucus secretion. Pheniramine also has anticholinergic properties and mild sedative effects due to its partial central nervous system penetration.

DOSAGE AND ADMINISTRATION

•      Adults: 0.5ml to 1ml (approximately 22.75mg) given intravenously (IV) at 1ml/min, or intramuscularly (IM), once or twice daily

•      Children (6 months to 3 years): 0.4ml to 1ml IM once or twice daily

•      Children (over 4 years): 0.8ml to 2ml IM once or twice daily

•      Intravenous doses should be administered slowly under medical supervision

•      Dose and frequency adjusted based on severity of the allergic reaction

SIDE EFFECTS

Common:

•      Drowsiness and sedation

•      Dry mouth, nose, and throat

•      Urinary retention

•      Gastrointestinal upset

Less common:

•      Palpitations and tachycardia at higher doses

•      Hallucinations, agitation, or disorientation, especially in children

•      Increased intraocular pressure

•      Blurred vision

NOT RECOMMENDED IN

•      Prostatic hypertrophy (enlarged prostate gland)

•      Known hypersensitivity to pheniramine or related antihistamines

•      Narrow-angle glaucoma

•      Should not be used in pregnancy without medical advice

•      Caution in patients with severe liver disease

DRUG INTERACTIONS

Pheniramine maleate has additive CNS depression effects when combined with alcohol, sedatives, hypnotics, opioids, or other CNS depressants, which can significantly increase the risk of excessive sedation. Concurrent use with monoamine oxidase inhibitors (MAOIs) can prolong and intensify the anticholinergic effects of pheniramine. Combination with tricyclic antidepressants amplifies anticholinergic side effects such as dry mouth, urinary retention, and constipation. Patients taking anticholinergic medications such as atropine should be monitored carefully for additive adverse effects.

STORAGE INSTRUCTIONS

Store Amrovil Injection at room temperature between 15°C and 25°C. Protect from light. Do not freeze. Discard unused portions of the vial after use. Keep out of reach of children.

WHERE TO BUY

Buy Amrovil Inj online from Dawa Healthcare Pharmacy, your dependable source for injectable antihistamine medications in Pakistan. Check the Amrovil Inj price in Pakistan and learn about Amrovil Inj uses through our expert pharmacist team. Same-day delivery in Karachi is available for urgent orders. Dawa Healthcare Pharmacy ships pharmaceutical injectables to patients and healthcare facilities across Pakistan through our nationwide courier network. Note: Glass injectable items are delivered within Karachi only.