AMKAY 100MG/2ML INJECTION ONLINE AT BEST PRICE IN PAKISTAN

GENERIC: Amikacin Sulphate 100mg/2ml

MANUFACTURER: Bosch Pharmaceuticals

QUANTITY:

5 ampoules per pack

INDICATION

Amkay 100mg Inj is an aminoglycoside antibiotic indicated for the treatment of serious and life-threatening bacterial infections caused by susceptible gram-negative organisms including Pseudomonas aeruginosa, Escherichia coli, Klebsiella, Enterobacter, Serratia, Acinetobacter, and Staphylococcus aureus. It is particularly valuable in infections caused by organisms resistant to gentamicin and tobramycin. It is used in nosocomial pneumonia, urinary tract infections, septicemia, bacterial endocarditis, peritonitis, and bone and joint infections.

MECHANISM OF ACTION

Amikacin is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A. It irreversibly binds to the 30S ribosomal subunit of susceptible bacteria, interfering with mRNA translation and causing misreading of the genetic code, resulting in production of non-functional proteins and bactericidal death. Its unique structural features make it resistant to most aminoglycoside-inactivating enzymes produced by resistant bacteria, retaining activity against many gentamicin and tobramycin-resistant gram-negative organisms. It is particularly valuable as a component of combination therapy for severe gram-negative infections.

DOSAGE AND ADMINISTRATION

• Adults: 15mg/kg/day in 2 or 3 divided doses by IM or IV injection

• Children: 15 to 22.5mg/kg/day in 2 to 3 divided doses

• Neonates: 7.5 to 10mg/kg every 12 to 24 hours based on gestational and postnatal age

• Therapeutic drug monitoring (peak and trough levels) is mandatory for safe and effective dosing; dose adjustment required in renal impairment

SIDE EFFECTS

Common:

• Nephrotoxicity: elevated creatinine and reduced urine output (monitor renal function daily)

• Ototoxicity: cochlear (hearing loss and tinnitus) and vestibular (dizziness, vertigo) damage

• Injection site pain with intramuscular administration

• Neuromuscular blockade at high doses

Less common:

• Irreversible hearing loss with prolonged use or excessive plasma levels

• Renal tubular necrosis with severe nephrotoxicity

• Hypersensitivity reactions including rash

• Hypomagnesaemia and hypokalaemia with prolonged therapy

NOT RECOMMENDED IN

• Known hypersensitivity to amikacin or other aminoglycosides (cross-sensitivity possible)

• Pre-existing severe renal impairment without dose adjustment and monitoring

• Concurrent use with other nephrotoxic or ototoxic agents without mandatory monitoring

• Myasthenia gravis (may exacerbate neuromuscular weakness)

DRUG INTERACTIONS

Other nephrotoxic agents including amphotericin B, vancomycin, and ciclosporin significantly increase nephrotoxicity risk; avoid or monitor intensively. Furosemide and other loop diuretics increase ototoxicity risk; avoid concurrent use. Neuromuscular blocking agents have potentiated effects with aminoglycosides; use with great caution in anaesthesia. NSAIDs reduce renal elimination of aminoglycosides. Cephalosporins are physically incompatible with aminoglycosides in the same syringe.

STORAGE INSTRUCTIONS

Store at room temperature between 15°C and 30°C. Protect from light and heat. Do not freeze. Keep out of reach of children.

WHERE TO BUY

You can buy Amkay 100mg/2ml Injection online from Dawa Healthcare Pharmacy at dawahealthcare.biz, one of Pakistan's most trusted pharmacies for authentic, pharmacist-verified medicines. Browse our product page to check the current Amkay 100mg/2ml Injection price in pakistan, read detailed clinical information, and place your order from the comfort of your home. Our experienced pharmacy team is always available to answer your questions about Amkay 100mg/2ml Injection uses and correct dosage. Customers in Karachi enjoy same-day delivery on orders placed before the daily cutoff, while customers across Pakistan benefit from our nationwide courier service for safe and timely delivery to any city. You can also visit any of our Karachi branches in person or reach our dedicated WhatsApp support team for instant help with Amkay 100mg/2ml Injection uses, pricing, prescriptions, and order placement.

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